报 告 人：Shang-tian Yang教授
Shang-Tian Yang现为美国俄亥俄州立大学化学与生物分子工程系教授，食品科学与技术、分子遗传学和生物化学研究生项目教授，自1985年以来一直在该校任教。Dr. Yang本科毕业于台湾大学，硕士、博士毕业于美国普渡大学，现担任俄亥俄州生物处理研究协会主任，并与多家公司在商业技术开发方面进行合作。Dr. Yang对生物工程有着广泛的研究兴趣，近年来主要进行生物催化、发酵过程工程、细胞与代谢工程、干细胞与组织工程、功能基因组学和用于高通量筛选及生物诊断的生物芯片等方面的研究，在生物过程工程领域发表350多篇期刊论文、会刊和著作章节，总被引次数超过12700次，高引因子H=64，拥有12项专利。Dr. Yang是两个生物技术创业公司的创始人之一，当选美国医学与生物工程协会fellow，《Process Biochemistry》副主编，美国化学工程师协会（AIChE）15部食品、制药和生物工程部的前任主席，美国化学学会（ACS）和生物工程学会活跃会员。
Biomass represents an abundant carbon-neutral renewable resource which can be converted to energy and chemicals to replace fossil fuels and petrochemicals. A biorefinery should utilize all components of biomass feedstock to produce energy, fuels and chemicals to maximize product values, minimize wastes generation, and improve process economics. Current biorefineries using corn, soybeans, and sugarcane for bioethanol and biodiesel production can benefit from integrated biorefining that is to extract high-value nutritional products while using the main feedstock component for biofuels production and further converting low-value byproducts to additional marketable products such as chemicals, energy (fuels, heat and electricity) and animal feed. Lignocellulosic biomass, including forestry and agricultural residues, as the second generation feedstock in biorefineries offers the opportunity to meet 30% of the nation’s fuel and chemical needs by 2030, although many technology challenges remain to overcome. In addition, aquacultures of micro- and macro-algae could provide all of the future fuel needs without constraining the current agriculture land use. To achieve sustainable fuels and chemicals production, new advances in process engineering and metabolic engineering for biomass conversion will be required. This seminar will focus on recent development of novel bioprocesses for production of biofuels and industrial chemicals currently produced mainly by petroleum-based chemical synthesis. The high oil price and environmental concerns over petroleum refinery prompted interests in producing biofuels and bio-based chemicals from renewable biomass via fermentation. Conventional fermentation processes for solvents and organic acids production are limited by low productivity and yield. However, metabolic and process engineering approaches can be used to greatly improve both the producing microorganism and the bioreactor performance, reducing the cost of the bio-based chemicals to an economically competitive level. Several bioprocesses using metabolically engineered microorganisms for butanol and carboxylic acids production from renewable biomass will be highlighted in this presentation.